CMR myocardial infarct evaluation in a canine model by three different contrast agents
نویسندگان
چکیده
We evaluated R1 curves, CNR and scar visualization and quantification in a dog model of myocardial infarction by CMR, using three different contrast agents: Gadopentate dimeglumine (Gd-DTPA, Magnevist), Gadobenate dimeglumine (Gd-BOPTA, MultiHance), and Gadofosveset (Ablavar). Gd-DTPA showed better characteristics for myocardial scar visualization and quantification. Gadofosveset demonstrated lower CNR and underestimation of infarct size when compared to Gd-DTPA.
منابع مشابه
Differentiation of acute and four-week old myocardial infarct with Gd(ABE-DTTA)-enhanced CMR
BACKGROUND Standard extracellular cardiovascular magnetic resonance (CMR) contrast agents (CA) do not provide differentiation between acute and older myocardial infarcts (MI). The purpose of this study was to develop a method for differentiation between acute and older myocardial infarct using myocardial late-enhancement (LE) CMR by a new, low molecular weight contrast agent.Dogs (n = 6) were s...
متن کاملIn vivo chronic myocardial infarction characterization by spin locked cardiovascular magnetic resonance
BACKGROUND Late gadolinium enhanced (LGE) cardiovascular magnetic resonance (CMR) is frequently used to evaluate myocardial viability, estimate total infarct size and transmurality, but is not always straightforward is and contraindicated in patients with renal failure because of the risk of nephrogenic systemic fibrosis. T2- and T1-weighted CMR alone is however relatively insensitive to chroni...
متن کاملThe regression of myocardial oedema in the first 3 months post ST-elevation MI in patients treated with primary angioplasty
Background Myocardial oedema and salvaged area at risk (ARA) have been described as markers of prognosis and as surrogate markers for clinical trials. The time-course of oedema has been described in a canine infarct model but the in vivo time course following revascularised MI has not been described. CMR is able to characterise oedema in myocardial tissue using T2-weighted sequences. We therefo...
متن کاملHow to measure myocardial infarct size by cardiac magnetic resonance imaging
In survivors of acute myocardial infarction (MI), the initial size of infarction is associated with long-term prognosis. This article addresses the role of contrast-enhanced cardiac magnetic resonance (CMR) imaging in determining the presence and extent of MI. Contrast-enhanced CMR is widely accepted as the reference method for imaging infarct size. The principles involved in contrast-enhanced ...
متن کاملDetermination of location, size, and transmurality of chronic myocardial infarction without exogenous contrast media by using cardiac magnetic resonance imaging at 3 T.
BACKGROUND Late-gadolinium-enhanced (LGE) cardiac MRI (CMR) is a powerful method for characterizing myocardial infarction (MI), but the requisite gadolinium infusion is estimated to be contraindicated in ≈20% of patients with MI because of end-stage chronic kidney disease. The purpose of this study is to investigate whether T1 CMR obtained without contrast agents at 3 T could be an alternative ...
متن کامل